Permethrin topical (for the skin) is used to treat head lice and scabies.

Permethrin topical may also be used for other purposes not listed in this medication guide.

Certificate of Analysis

• Description

  Yellow coloured liquid which solidity on standing at lower temperature.

  Result

  Yellow brownish colour liquid which may solidity on standing at lower temperature.

• Solubility

  Soluble in Alcohol(96% w/v), Acetone, ether & hydrocarbons (Toluene)

  Result

  Soluble in Alcohol(96% w/v), Acetone, ether & hydrocarbons (Toluene)

• Identification By IR

  IR spectrum exhibits maxima which are only at same wave number as those in spectrum permethrin standard.

  Result

  The IR spectrum of the sample is concordant with the spectrum obtained with permethrin standard.

• Identification By HPLC

  Retention time of permethrin test sample matches with retention time of permethrin standard in the assay test.

  Result

  Retention time of permethrin test sample matches with retention time of permethrin standard in the assay test.

• Loss on Drying

  0.37 %

  Result

  NMT 2.0 %

• Sulphated ash

  0.10 %

  Result

  NMT 0.2 %

• Assay by HPLC(on dried basis)

  99.87 %

  Result

  NMT 95.0%

• Cis Isomer

  25.68 %

  Result

  23.0 % to 27.0 %

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Material Safety Data Sheet

• Section 1 – Chemical Product

  Product Identifier

  Permethrin

  MSDS Prepared By

  R&D Department

• Section 2 – Composition / Information Of Ingredients

  Product Name

  Permethrin

  Synonym

  PERMETHRIN (FMC 33297): 3-phenoxybenzyl (1RS,3RS;1RS,3SR)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate or 3-phenoxybenzyl (1RS)-cis-trans-3-(2,2-dichlorovinyl)-2,2- dimethylcyclopropanecarboxylate (IUPAC name); (3phenoxyphenyl) methyl 3-(2,2-dichloroethenyl) -2,2dimethylcyclopropanecarboxylate

  Molecular Weight (%)

  36.8%

  CAS No

  52645-53-1

• Section 3 – HAZARDOUS IDENTIFICATION

  Classification

  OSHA Regulatory Status

  This material should consider hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200)

  Acute toxicity – Oral

  Category 4

  Acute toxicity – Inhalation (Dusts/Mists)

  Category 4

  Skin sensitization

  Category 1B

  Specific target organ toxicity (single exposure)

  Category 2

  Specific target organ toxicity (repeated exposure)

  Category 2

  Aspiration toxicity

  Category 1

  Emergency Overview Hazard Statements

  H302

  Harmful if swallowed.

  H304

  May be fatal if swallowed & enters airways.

  H317

  May cause an allergic skin reaction.

  H332

  Harmful if inhaled.

  H371

  May cause damage to organs.

  H373

  May cause damage to organs through prolonged or repeated exposure.

  Precautionary Statements – Prevention

  P264

  Wash face, hands and any exposed skin thoroughly after handling.

  P270

  Do not eat, drink or smoke when using this product.

  P272

  Contaminated work clothing should not be allowed out of the workplace.

  P280

  Wear protective gloves

  P260

  Do not breathe Dust / Fume / Gas / Mist. / Vapors / Spray.

  Precautionary Statements – Response

  P308 + P311

  If exposed or concerned: Call a POISON CENTER or doctor.

  P302 + P352

  IF ON SKIN: Wash with plenty of water and soap.

  P333 + P313

  If skin irritation or rash occurs: Get medical advice/attention.

  P363

  Wash contaminated clothing before reuse.

  P304 + P340

  IF INHALED: Remove person to fresh air and keep comfortable for breathing.

  P312

  Call a POISON CENTER or doctor if you feel unwell.

  P301 + P310

  IF SWALLOWED: Immediately call a POISON CENTER or doctor .

  P331

  Do NOT induce vomiting.

  P330

  Rinse mouth

  Precautionary Statements – Storage

  P405

  Store locked up.

  Precautionary Statements – Disposal

  P501

  Dispose of contents/container to an approved waste disposal plant.

  Hazards not otherwise classified (HNOC)

  No hazards not otherwise classified were identified.

  Other Information

  Very toxic to aquatic life with long lasting effects. Causes mild skin irritation. May be harmful in contact with skin.

• Section 4 – FIRST AID

  Eye Contact

  Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call a poison control center or doctor for further treatment advice.

  Skin Contact

  Take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes. Call a poison control center or doctor for further treatment advice.

  Inhalation

  Move to fresh air. If person is not breathing, call 911 or an ambulance, then give artificial respiration, preferably mouth-to-mouth if possible. Call a poison control center or doctor for further treatment advice.

  Ingestion

  Immediately call a poison control center or doctor. Do not induce vomiting unless told to do so by a poison control center or doctor. Do not give any liquid to the person. Do not give anything by mouth to an unconscious person.

  Most important symptoms and effects, both acute and delayed

  Central nervous system effects.

  Indication of immediate medical attention and special treatment needed, if necessary

  This product is a pyrethroid. If large amounts have been ingested, the stomach and intestines should be evacuated. Treatment is symptomatic and supportive. Digestible fats, oils, or alcohol may increase absorption and so should be avoided. Contains petroleum distillate. Vomiting may cause aspiration pneumonia.

• Section 5 – FIRE FIGHTING MEASURES

  Suitable Extinguishing Media

  Foam, carbon dioxide (CO2). Dry chemical. Water spray or fog.

  Specific Hazards Arising from the Chemical

  Combustible Liquid

  Explosion Data

  Sensitivity to Mechanical Impact

  N/A

  Sensitivity to Static Discharge

  N/A

  Protective equipment and precautions for firefighters

  As in any fire, wear self-contained breathing apparatus and full protective gear. Isolate fire area. Evaluate upwind.

• Section 6 – ACCIDENT RELEASE MEASURES

  Personal Precautions

  Isolate & post spill area. Remove all sources of ignition. Wear suitable protective clothing, gloves & eye/face protection. For personal protection see Section 8.

  Environmental Precautions

  Keep people & animals away from & upwind of spill/leak. Keep material out of lakes, streams, ponds & sewer drains. Keep out of waterways.

  Methods of Containment

  Dike to prevent runoff. Absorb with earth, sand or other non-combustible material & transfer to containers for later disposal.

  Methods for Cleaning Up

  Clean & neutralize spill area, tools & equipment by washing with water & soap. Absorb rinse & add to the collected waste. Waste must be classified & labeled prior to recycling or disposal. Dispose of waste as indicated in Section 13.

• Section 7 – HANDLING AND STORAGE

  Handling

  Do not contaminate other pesticides, fertilizers, water, food, or feed by storage or disposal.

  Storage

  Keep in a dry, cool and well-ventilated place. Keep away from open flames, hot surfaces and sources of ignition. Keep out of reach of children and animals. Keep/store only in original container.

  Incompatible Products

  Not known

• Section 8 – EXPOSURE CONTROLS / PERSONAL PROTECTION

  Engineering Measures

  Apply technical measures to comply with the occupational exposure limits. Ensure adequate ventilation, especially in confined areas. When working in confined spaces (tanks, containers, etc.), ensure that there is a supply of air suitable for breathing and wear the recommended equipment.

  Personal Protective Equipment

  Eye/Face Protection

  If there is a potential for exposure to particles which could cause eye discomfort, wear chemical goggles.

  Skin & Body Protection

  Wear long-sleeved shirt, long pants, socks, and shoes.

  Hand Protection

  Protective gloves

  Respiratory Protection

  If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved respiratory protection should be worn. Respiratory protection must be provided in accordance with current local regulations.

  Hygiene Measures

  Clean water should be available for washing in case of eye or skin contamination. Wash skin prior to eating, drinking, chewing gum or using tobacco. Shower or bathe at the end of working. Remove and wash contaminated clothing before re-use. Launder work clothing separately from regular household laundry.

  General information

  If the product is used in mixtures, it is recommended that you contact the appropriate protective equipment suppliers.

• Section 9 – PHYSICAL AND CHEMICAL PROPERITIES

  Appearance

  Amber Liquid

  Physical State

  Liquid

  Color

  Amber

  Odor

  Faint Hydrocarbon

  Odor Threshold

  N/A

  Melting / Freezing Point

  N/A

  Boiling Point

  N/A

  Flash Point

  82.2°C / 179.96°F Tag Closed Cup

  Evaporation Rate

  N/A

  Flammability (Solid, Gas)

  N/A

  Lower Flammability Limit

  N/A

  Upper Flammability Limit

  N/A

  Vapor Pressure

  N/A

  Vapor Density

  N/A

  Density

  8.61 lb/gal

  Specific Gravity

  1.0333 @ 20°C

  Water Solubility

  Emulsifies

  Solubility in other Solvents

  N/A

  Partition Coef.

  N/A

  Autoignition Temperature

  N/A

  Decomposition Temperature

  N/A

  Viscosity, kinematic

  N/A

  Viscosity, dynamic

  N/A

  Explosive Properties

  N/A

  Oxidizing Properties

  N/A

  Bulk Density

  N/A

• Section 10 – STABILITY AND REACTIVITY

  Reactivity

  None under normal use conditions.

  Chemical Stability

  Stable under recommended storage conditions.

  Possibility of Hazardous Reactions

  None under normal processing.

  Hazardous polymerization

  Hazardous polymerization does not occur.

  Conditions to avoid

  Excessive heat, Extreme risk of explosion by shock, friction, fire or other sources of ignition

  Incompatible materials

  None known.

  Hazardous Decomposition Products

  Chlorine, hydrogen chloride, Carbon oxides (COx), Aldehydes.

• Section 11 – TOXICOLOGICAL INFORMATION

  Product Information

  LD50 Oral

  998 mg/kg (rat)

  LD50 Dermal

  Less than 2000 mg/kg (rabbit)

  LD50 Inhalation

  Less than 4.3 mg/L 4 hr (rat)

  Skin Corrosion / Irritation

  Moderately irritating.

  Serious Eye Damage / Irritation

  Mildly irritating

  Sensitization

  Sensitizer

  Information on Toxicological Effects

  Symptoms

  Large toxic doses of the formulated product, administered by ingestion to animals, produced central nervous system effects with symptoms that include hypersensitivity to touch and sound, tremors, and clinic convulsions. Overexposure via inhalation produced symptoms such as squinting eyes, irregular and rattling breathing, and ataxia.

  Delayed and immediate effects as well as chronic effects from short and long-term exposure

  Chronic Toxicity

  Effects are expected to be similar to those that are seen with acute toxicity.

  Mutagenicity

  Not genotoxic in laboratory studies.

  Carcinogenicity

  Evidence of tumors in mice but is not considered relevant to humans.

  Neurological Effects

  Clinical signs of neurotoxicity include altered motor activity and FOB effects, with no signs of histopathology.

  Reproductive Toxicity

  No toxicity to reproduction in animal studies.

  Developmental Toxicity

  Not teratogenic in animal studies.

  STOT Single Exposure

  May cause damage to organs. See listed target organs below.

  STOT – repeated exposure

  May cause damage to organs through prolonged or repeated exposure. See listed target organs below.

  Target organ effects

  Central Nervous System (CNS).

  Neurological effects

  Clinical signs of neurotoxicity include altered motor activity and FOB effects, with no signs of histopathology.

• Section 12 – ECOLOGICAL INFORMATION

  Persistence & Degradability

  Moderately persistent. Does not readily hydrolyze. Not readily biodegradable.

  Bioaccumulation

  The substance has a potential for bioconcentration.

  Mobility

  Immobile; Not expected to reach groundwater.

• Section 13 – DISPOSAL CONSIDERATION

  Waste disposal methods

  Pesticide wastes are toxic. Improper disposal of excess pesticide, spray mixture, or rinsate is prohibited. If these wastes cannot be disposed of by use according to label instructions, contact appropriate disposal authorities for guidance. Proper personal protective equipment, as described in Sections 7 and 8, must be worn while handling materials for waste disposal.

  Contaminated Packaging

  Containers must be disposed of in accordance with local, state and federal regulations. Refer to the product label for container disposal instructions.

• Section 14 – TRANSPORT INFORMATION

  DOT

  DOT

  The classification below pertains to the shipment in bulk and non-bulk packaging.

  UN/ID No

  NA1993

  Proper Shipping Name

  Combustible liquid, n.o.s

  Hazard Class

  Combustible

  Packing Group

  III

  Description

  NA1993, Combustible liquid, n.o.s. (Aromatic hydrocarbons), III

  TDG

  TDG

  Classification below is only applicable when shipped by vessel and is not applicable when shipped by road or rail only.

  UN/ID No

  UN3082

  Proper Shipping Name

  Environmentally hazardous substance, liquid, n.o.s.

  Hazard Class

  9

  Packing Group

  III

  Marine Pollutant

  Permethrin

  Description

  UN3082, Environmentally hazardous substance, liquid, n.o.s. (permethrin), 9, PGIII, Marine Pollutant

  ICAO/IATA

  UN/ID No

  UN3082

  Proper Shipping Name

  Environmentally hazardous substance, liquid, n.o.s.

  Hazard Class

  9

  Packing Group

  III

  Description

  UN3082, Environmentally hazardous substance, liquid, n.o.s. (permethrin), 9, PGIII, Marine Pollutant

  IMDG/IMO

  UN/ID No

  UN3082

  Proper Shipping Name

  Environmentally hazardous substance, liquid, n.o.s.

  Hazard Class

  9

  Packing Group

  III

  Marine Pollutant

  Permethrin

  Description

  UN3082, Environmentally hazardous substance, liquid, n.o.s. (permethrin), 9, PGIII, Marine Pollutant

• Section 15 – REGULATORY INFORMATION

  U.S. Federal Regulations

  SARA 313

  Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product contains a chemical or chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.

  SARA 311/312 Hazard Categories

  Acute Health Hazard

  Yes

  Chronic Health Hazard

  Yes

  Fire Hazard

  Yes

  Sudden release of pressure Hazard

  No

  Reactive Hazard

  No

  Clean Water Act

  This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40 CFR 122.42).

  CERCLA

  This material, as supplied, contains one or more substances regulated as a hazardous substance under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302).

  FIFRA Information

  This chemical is a pesticide product registered by the Environmental Protection Agency and is subject to certain labeling requirements under federal pesticide law. These requirements differ from the classification criteria and hazard information required for safety data sheets, and for workplace labels of non-pesticide chemicals. Following is the hazard information as required on the pesticide label.

  Caution

  Harmful if swallowed. Harmful if absorbed through the skin. Prolonged or frequent skin contact may cause allergic reactions in some individuals. This product is extremely toxic to fish and aquatic invertebrates.

  US State Regulations

  California Proposition 65

  This product does not contain any Proposition 65 chemicals.

  Mexico – Grade

  Moderate risk

  Grade 2

  WHMIS Statement

  This product has been classified in accordance with the Hazardous Products Regulations (HPR) and the SDS contains all the information required by the HPR.

  WHMIS Hazard Class

  D2B

  Toxic materials

  National Fire Protection Association (NFPA)

  Health Hazard

  2

  Flammability

  2

  Instability

  0

  Special Hazard

  N/A

  Health Management Information System (HMIS)

  Health Hazard

  2

  Flammability

  2

  Physical Hazard

  0

  Personal Protection

  X

• Section 16 – OTHER INFORMATION

  Global Pharma provides information contained herein in good faith but makes no representation as to its comprehensives or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product.

  Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose.

  GLOBAL PHARMA MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESSED OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OR MERCHANTABILITY, FITNESS FOR A PARTICULER PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT WHICH THE INFORMATION REEFERS. GLOBAL PHARMA WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF RELIANCE UPON THIS INFORMATION.